Global stability of an infection-age structured HIV-1 model linking within-host and between-host dynamics. (English) Zbl 1371.92130
Summary: Although much evidence shows the inseparable interaction between the within-host progression of HIV-1 infection and the transmission of the disease at the population level, few models coupling the within-host and between-host dynamics have been developed. In this paper, we adopt the nested approach, viewing the transmission rate at each stage (primary, chronic, and AIDS stage) of HIV-1 infection as a saturated function of the viral load, to formulate an infection-age structured epidemic model. We explicitly link the individual and the host population scale, and derive the basic reproduction number \(R_0\) for the coupled system. To analyze the model and perform a detailed global dynamics analysis, two Lyapunov functionals are constructed to prove the global asymptotical stability of the disease-free and endemic equilibria. Theoretical results indicate that \(R_0\) provides a threshold value determining whether or not the disease dies out. Numerical simulations are presented to quantitatively investigate the influence of the within-host viral dynamics on between-host transmission dynamics. The results suggest that increasing the effectiveness of inhibitors can decrease the basic reproduction number, but can also increase the overall infected population because of a lower disease-induced mortality rate and a longer lifespan of HIV infected individuals.
Keywords:
HIV-1 infection; infection-age; nested model; saturated function; global asymptotical stability; Lyapunov functional,References:
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