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HLA-DMA

From Wikipedia, the free encyclopedia

HLA-DMA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHLA-DMA, D6S222E, DMA, HLADM, RING6, major histocompatibility complex, class II, DM alpha
External IDsOMIM: 142855; MGI: 95921; HomoloGene: 4464; GeneCards: HLA-DMA; OMA:HLA-DMA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006120

NM_010386
NM_001360530

RefSeq (protein)

n/a

NP_034516
NP_001347459

Location (UCSC)Chr 6: 32.95 – 32.97 MbChr 17: 34.34 – 34.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.[5][6]

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.[6]

References

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  1. ^ a b c ENSG00000243719, ENSG00000239463, ENSG00000204257, ENSG00000242361, ENSG00000241394, ENSG00000243189, ENSG00000242685 GRCh38: Ensembl release 89: ENSG00000243215, ENSG00000243719, ENSG00000239463, ENSG00000204257, ENSG00000242361, ENSG00000241394, ENSG00000243189, ENSG00000242685Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037649Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (Nov 1991). "Second proteasome-related gene in the human MHC class II region". Nature. 353 (6345): 667–8. Bibcode:1991Natur.353..667K. doi:10.1038/353667a0. PMID 1922385. S2CID 4344064.
  6. ^ a b "Entrez Gene: HLA-DMA major histocompatibility complex, class II, DM alpha".

Further reading

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