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DEK (gene)

From Wikipedia, the free encyclopedia
DEK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDEK, D6S231E, DEK proto-oncogene
External IDsOMIM: 125264; MGI: 1926209; HomoloGene: 2593; GeneCards: DEK; OMA:DEK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134709
NM_003472

NM_025900

RefSeq (protein)

NP_001128181
NP_003463

NP_080176

Location (UCSC)Chr 6: 18.22 – 18.26 MbChr 13: 47.24 – 47.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human DEK gene encodes the DEK protein.[5][6]

Function

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This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[6]

Interactions

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DEK interacts with TFAP2A.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124795Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021377Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. doi:10.1128/mcb.12.4.1687. PMC 369612. PMID 1549122.
  6. ^ a b "Entrez Gene: DEK DEK oncogene (DNA binding)".
  7. ^ Campillos M, García MA, Valdivieso F, Vázquez J (Mar 2003). "Transcriptional activation by AP-2alpha is modulated by the oncogene DEK". Nucleic Acids Res. 31 (5): 1571–5. doi:10.1093/nar/gkg247. PMC 149840. PMID 12595566.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK