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Cephalosporin-C deacetylase

From Wikipedia, the free encyclopedia
cephalosporin-C deacetylase
Identifiers
EC no.3.1.1.41
CAS no.52227-71-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme cephalosporin-C deacetylase (EC 3.1.1.41) catalyzes the reaction

cephalosporin C + H2O deacetylcephalosporin C + acetate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is cephalosporin-C acetylhydrolase. Other names in common use include cephalosporin C acetyl-hydrolase, cephalosporin C acetylase, cephalosporin acetylesterase, cephalosporin C acetylesterase, cephalosporin C acetyl-esterase, and cephalosporin C deacetylase. This enzyme participates in penicillin and cephalosporin biosynthesis.

Structural studies

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As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1L7A, 1ODS, 1ODT, and 1VLQ.

References

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  • Fujisawa Y, Shirafugi H, Kida M, Nara K, Yoneda M, Kanzaki T (1973). "New findings on cephalosporin C biosynthesis". Nat. New Biol. 246 (153): 154–5. doi:10.1038/newbio246154a0. PMID 4519146.