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ADGRL2

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ADGRL2
Identifikatori
AliasiADGRL2
Vanjski ID-jeviOMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za ADGRL2
Genomska lokacija za ADGRL2
Bend1p31.1Početak81,306,147 bp[1]
Kraj81,993,932 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za ADGRL2
Genomska lokacija za ADGRL2
Bend3|3 H3Početak148,815,583 bp[2]
Kraj148,990,555 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija G protein-coupled receptor activity
transmembrane signaling receptor activity
latrotoxin receptor activity
signal transducer activity
carbohydrate binding
Ćelijska komponenta integral component of membrane
membrana
intracellular anatomical structure
integral component of plasma membrane
neuron projection
Biološki proces G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
GO:0072468 Transdukcija signala
adenylate cyclase-activating G protein-coupled receptor signaling pathway
brain development
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001297704
NM_001297705
NM_001297706
NM_012302
NM_001330645

NM_001350698
NM_001350699
NM_001366002
NM_001366003
NM_001366004
NM_001366005
NM_001366006
NM_001366007
NM_001366008
NM_001366009
NM_001393349
NM_001393350
NM_001393351
NM_001393352
NM_001393353
NM_001393354

NM_001081298

RefSeq (bjelančevina)
NP_001284633
NP_001284634
NP_001284635
NP_001317574
NP_036434

NP_001337627
NP_001337628
NP_001352931
NP_001352932
NP_001352933
NP_001352934
NP_001352935
NP_001352936
NP_001352937
NP_001352938

NP_001074767
NP_001392915
NP_001392916
NP_001392917
NP_001392918

NP_001392919
NP_001392920
NP_001392921
NP_001392922
NP_001392923
NP_001392924
NP_001392925
NP_001392926
NP_001392927
NP_001392928
NP_001392929
NP_001392930
NP_001392931
NP_001392932
NP_001392933
NP_001392934
NP_001392935
NP_001392936
NP_001392937
NP_001392938
NP_001392939
NP_001392940
NP_001392947
NP_001392948

Lokacija (UCSC)Chr 1: 81.31 – 81.99 MbChr 3: 148.82 – 148.99 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Latrofilin 2 jest protein koji je kod ljudi kodiran genom ADGRL2 sa hromosoma 1.[5][6]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.459 aminokiselina, a molekulska težina 163.349 Da.[6]

1020304050
MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLR
CPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNR
TQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIY
EAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTT
YKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANY
HDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA
TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNR
GEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQV
PTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKPPPAV
STTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTA
SYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHT
KGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK
TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFV
LADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLS
ANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVN
SHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMG
YWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVI
TWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG
IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRK
KYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTF
IILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLT
WSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFR
HSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSES
SFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP
SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDC
GLSLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDA
IVADASSLMHSDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDS
YVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRS
ENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVRE
GQMQLVTSL

Funkcija

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Ovaj gen kodira člana potporodice latrofilinskih receptora vezanih za G-protein (GPCR). Latrofilini mogu funkcionirati i u ćelijskoj adheziji i u prijenosu signala. U eksperimentima s neljudskim vrstama, endogeno proteolitsko cijepanje unutar cisteinom bogatog GPS domena (mjesto proteolize G-protein spregnutog receptora) rezultiralo je u dvije podjedinice (velika vanćelijska N-terminal podjedinica ćelijske adhezije i podjedinica sa značajnom sličnošću sa porodica sekretin/kalcitonin GPCR-a) koji su nekovalentno vezani na ćelijskoj membrani. Iako je opisano nekoliko varijanti transkripta, utvrđena je biološka valjanost samo jedne.[6]

Također pogledajte

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Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
  6. ^ a b c "Entrez Gene: LPHN2 latrophilin 2".

Dopunska literatura

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Vanjski linkovi

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Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.