William Calman Grahame, known as W. C. Grahame, (3 February 1863 – 15 September 1945) was a member of the New South Wales Legislative Assembly, representing Wickham from 1907 to 1920. Grahame served as Minister for Agriculture under Premier William Holman in both the Labor ministry and Nationalist ministry. Wickham was abolished in 1920, with the introduction of proportional representation and combined with Newcastle and Grahame unsuccessfully stood as an independent at the 1920 election for Newcastle.