About: SIB-1893

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SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. It has anticonvulsant and neuroprotective effects, and reduces glutamate release. It has also been found to act as a positive allosteric modulator of mGluR4.

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dbo:abstract
  • SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. It has anticonvulsant and neuroprotective effects, and reduces glutamate release. It has also been found to act as a positive allosteric modulator of mGluR4. (en)
  • SIB-1893是一种有机化合物,化学式为C14H13N。它可由2-甲基-6-苯乙炔基吡啶和硫化钠九水合物在二甲基甲酰胺中于140 °C反应制得。以苯甲醛和2,6-二甲基吡啶为原料在路易斯酸催化下反应,也可得到该化合物。在草酸二水合物的存在下,它可以发生光二聚反应,得到1,3-二苯基-2,4-二(6-甲基吡啶-2-基)环丁烷。 (zh)
dbo:casNumber
  • 7370-21-0
dbo:chEMBL
  • 88612
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  • 4X2F5X24UK
dbo:pubchem
  • 235382
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  • SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5. It has anticonvulsant and neuroprotective effects, and reduces glutamate release. It has also been found to act as a positive allosteric modulator of mGluR4. (en)
  • SIB-1893是一种有机化合物,化学式为C14H13N。它可由2-甲基-6-苯乙炔基吡啶和硫化钠九水合物在二甲基甲酰胺中于140 °C反应制得。以苯甲醛和2,6-二甲基吡啶为原料在路易斯酸催化下反应,也可得到该化合物。在草酸二水合物的存在下,它可以发生光二聚反应,得到1,3-二苯基-2,4-二(6-甲基吡啶-2-基)环丁烷。 (zh)
rdfs:label
  • SIB-1893 (en)
  • SIB-1893 (zh)
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