About: Depressogen

An Entity of Type: Thing, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase in

Property Value
dbo:abstract
  • A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase inhibitor), and clomiphene (a SERM), as well as others including flunarizine, mefloquine, and efavirenz. Another notable agent is rimonabant, a cannabinoid receptor antagonist marketed as an anti-obesity agent which was withdrawn shortly after its introduction due to the incidence of severe psychiatric side effects associated with its use including depression, anxiety, and suicidal ideation. Examples of endogenous compounds that have been implicated in stress and depression include corticotropin-releasing hormone (CRH), cytokines (e.g., interferon-α, interleukin-2), tachykinins (e.g., substance P), glucocorticoids (e.g., cortisol, cortisone), and dynorphin. (en)
dbo:wikiPageID
  • 35805638 (xsd:integer)
dbo:wikiPageLength
  • 5277 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1100195976 (xsd:integer)
dbo:wikiPageWikiLink
dbp:date
  • March 2021 (en)
dbp:reason
  • Convert long prose list to bulleted list. (en)
dbp:wikiPageUsesTemplate
dcterms:subject
rdfs:comment
  • A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase in (en)
rdfs:label
  • Depressogen (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is owl:differentFrom of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License