[Mechanism study of adaptive response in high background radiation area of Yangjiang in China]
- PMID: 21092626
[Mechanism study of adaptive response in high background radiation area of Yangjiang in China]
Abstract
Objective: To study the adaptive response mechanisms in high background radiation area (HBRA) among Yangjiang local people through gene and protein expression of receptor for advanced glycation end products (RAGE) and S100A6 in peripheral blood and sputum in inhabitants of HBRA.
Methods: A total of 53 male inhabitants were selected from HBRA in Yangjiang as the exposure group, while 53 male inhabitants were selected from Enping (control area, CA)as the control group. The content of RAGE and S100A6 gene and protein were detected by RT-PCR and Western blotting assay. Thermo luminescent dosemeter(TLD) assay was used to measure the outside dose and estimate the effective dose.
Results: The effective dose in CA and HBRA was respectively 1.95 mSv and 6.24 mSv, which was 3 fold difference. Compared with CA, RAGE and S100A6 expression were significantly reduced in both gene and protein level in HBRA. The relative median mRNA expression of RAGE and S100A6 in peripheral blood were respectively 0.28, 1.06 and 0.16, 0.79 in CA and HBRA group, there was significance (with analysis Z values of -2.587 and -2.328 respectively, P < 0.05) with Wilcoxon rank test. For the protein of sputum, the relative median expression were respectively 2.98, 2.25 and 0.53, 0.47 with significant difference (with analysis Z values of -2.201 and -2.366 respectively, P < 0.05) by Wilcoxon rank test.
Conclusion: The low expression of RAGE and S100A6 in HBRA group might be correlated with the adaptive response and the low mortality of cancer in HBRA.
Similar articles
-
[Cancer mortality in high background radiation area of Yangjiang, China, 1979-1995].Zhonghua Yi Xue Za Zhi. 1999 Jul;79(7):487-92. Zhonghua Yi Xue Za Zhi. 1999. PMID: 11715418 Chinese.
-
Chromosome aberration, cancer mortality and hormetic phenomena among inhabitants in areas of high background radiation in China.J Radiat Res. 1991 Dec;32 Suppl 2:46-53. J Radiat Res. 1991. PMID: 1823366 Review.
-
[Epidemiological survey in a high background radiation area in Yangjiang, China].Zhonghua Liu Xing Bing Xue Za Zhi. 1996 Dec;17(6):328-32. Zhonghua Liu Xing Bing Xue Za Zhi. 1996. PMID: 9387595 Chinese.
-
Cancer mortality in the high background radiation areas of Yangjiang, China during the period between 1979 and 1995.J Radiat Res. 2000 Oct;41 Suppl:31-41. doi: 10.1269/jrr.41.s31. J Radiat Res. 2000. PMID: 11142210
-
The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: arguing against the motion.Mol Nutr Food Res. 2007 Sep;51(9):1116-9. doi: 10.1002/mnfr.200600284. Mol Nutr Food Res. 2007. PMID: 17854011 Review.
Cited by
-
S100A6 Protein-Expression and Function in Norm and Pathology.Int J Mol Sci. 2023 Jan 10;24(2):1341. doi: 10.3390/ijms24021341. Int J Mol Sci. 2023. PMID: 36674873 Free PMC article. Review.
-
Radon Hazard in Central Italy: Comparison among Areas with Different Geogenic Radon Potential.Int J Environ Res Public Health. 2022 Jan 7;19(2):666. doi: 10.3390/ijerph19020666. Int J Environ Res Public Health. 2022. PMID: 35055494 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources