- In the middle of nowhere, with only a two-lane highway to connect it to anywhere, a recently divorced woman traveler, who's a passenger on a bus that has broken down, gets caught in a bizarre and violent turf war between serial killers.
- When a bus breaks down on a deserted road in the middle of a forest, passenger Stacia decides to walk the 20 km to a motel. Another pair of bus travelers - Birdy and Danny - get a lift from a truck driver who happens to be a crazed psychotic killer. The paranoid Marie and her husband - terrified of what might be 'out there' - stay on the bus with the driver awaiting help. Soon, a hitchhiker comes to the bus. Can he help or is he only more to fear?—Claudio Carvalho, Rio de Janeiro, Brazil
- In the middle of nowhere, with only a two-lane highway to connect it to anywhere, a divorcee who is a passenger on a bus that has broken down, gets caught in a strange, violent turf war between two serial killers: a truck driver with a slur and a hitchhiker with a twang.—MuzikJunky
- On a two-lane highway that resembles Route 28 in upstate New York, two serial killers clash in a turf war: one is named Wheeler (Michael Moriarty) a truck driver who kills hitchhikers he picks, and the other is named Walker (Warren Kole) who is a hitchhiker who murders whomever gives him a ride. Stacia (Fairuza Balk), a recently divorced woman, falls in between the clash of the killers.
After a transport bus breaks down, the driver and passengers, save for Stacia who left previously, are murdered by either of the two twisted killers. Fascinated, Wheeler and Walker examine each others' kills. Wheeler murders a woman (Laurene Landon) and hangs her body in the truck, and pistol whips and decapitates a man with the sliding door of the luggage compartment. Walker garrotes the bus driver with a dead snake, shoots a passenger, leaves another passenger to die tied by her wrists to a tree and wrapped in barbed wire (whom Wheeler finds alive and taunts), slaughters a punk, and partially skins his girlfriend before killing her.
Later, at a roadside motel, the two psychopaths play head games with each other and Stacia, clashing over who will be Stacia's killer. As she is leaving the motel, Wheeler offers her a ride then assaults and handcuffs Stacia while driving. He comes across Walker on the highway, standing in the lane, and brakes to a stop just before hitting him. Walker accepts a ride, and the two bicker and draw their pistols, ready to kill Stacia and each other. Stacia, sitting in the middle, slams on the brakes and sends the two murderous men through the windshield onto the road and causes the truck's cab to fall on its side. Stacia unsuccessfully struggles to get Wheeler's gun, while the wounded Wheeler and Walker fight to determine who will kill her as an ambulance siren sounds.
In the end, Wheeler and Walker are side by side in the ambulance, still fighting and cursing at one another. Finally, they cease, as Walker points out how much fun the two off them could have with an ambulance, revealing that he still has his craft knife he used to torture the stoner's girlfriend. However, one of the EMTs rams syringes into their chests, apparently killing them both, as the new killer tells the driver that they plan to save Stacia (bound and gagged in an upper bunk of the ambulance) for later. Stacia is now a helpless captive of another pair of serial killers whom are the two ambulance attendents whom kill whomever they pick up.
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