This was Janet Gaynor's final film. It was also her first film since The Young in Heart (1938) 19 years earlier.
This was Pat Boone's first film under a seven year contract he signed with 20th Century-Fox. "Bernardine" and its follow-up "April Love" were successful enough that Boone ranked #3 on the Top Ten Box Office Stars list for 1957, but he would never make the list again.