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Journal of Mammary Gland Biology and Neoplasia
Secretion and Fluid Transport Mechanisms in the Mammary Gland: Comparisons with the Exocrine Pancreas and the Salivary Gland2006 •
2013 •
JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS
Journal of Biomolecular Structure and Dynamics Disorder in milk proteins: adipophilin and TIP47, important constituents of the milk fat globule membrane2019 •
Milk fat globules (MFGs), which are secreted by the epithelial cells of the lactating mammary glands, account for the most of the nutritional value of milk. They are enveloped by the milk fat globule membrane (MFGM), a complex structure consisting of three phospholipid membrane monolayers and containing various lipids. Depending on the origin of milk, specific proteins accounts for 5–70% of the MFGM mass. Proteome of MFGMs includes hundreds of proteins, with nine major components being adipophilin, butyrophilin, cluster of differentiation 36, fatty acid binding protein, lactadherin, mucin 1, mucin 15, tail-interacting protein 47 (TIP47), and xanthine oxidoreductase. Two of the MFGM components, adipophilin and TIP47, belong to the five-member perilipin family of lipid droplet proteins. Adipophilin is involved in the formation of cytoplasmic lipid droplets and secretion of MFGs. This protein is also related to the formation of other lipid droplets that exist in most cell types, playing an important role in the transport of lipids from ER to the surface of lipid droplets. TIP47 acts as a cytoplasmic sorting factor for mannose 6-phosphate receptors and is recruited to the MFGM. Therefore, both adipophilin and TIP47 are moonlighting proteins, each possessing several unrelated functions. This review focuses on the main functions and specific structural features of adipophilin and TIP47, analyzes similarities and differences of these proteins among different species, and describes these proteins in the context of other members of the perilipin family.
2013 •
Cell and Tissue Research
The distribution of MUC1, an apical membrane glycoprotein, in mammary epithelial cells at the resolution of the electron microscope: implications for the mechanism of milk secretion2001 •
Journal of dairy science
A review and proposed nomenclature for major proteins of the milk-fat globule membrane2000 •
The characteristics and possible functions of the most abundant proteins associated with the bovine milk-fat globule membrane are reviewed. Under the auspices of the Milk Protein Nomenclature Committee of the ADSA, a revised nomenclature for the major membrane proteins is proposed and discussed in relation to earlier schemes. We recommend that proteins be assigned specific names as they are identified by molecular cloning and sequencing techniques. The practice of identifying proteins according to their Mr, electrophoretic mobility, or staining characteristics should be discontinued, except for uncharacterized proteins. The properties and amino acid sequences of the following proteins are discussed in detail: MUC1, xanthine dehydrogenase/oxidase, CD36, butyrophilin, adipophilin, periodic acid Schiff 6/7 (PAS 6/7), and fatty acid binding protein. In addition, a compilation of less abundant proteins associated with the bovine milk-fat globule membrane is presented.
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European Journal of Cell Biology
Characterisation of the potential SNARE proteins relevant to milk product release by mouse mammary epithelial cells2011 •
Journal of Biological Chemistry
Butyrophilin Is Expressed in Mammary Epithelial Cells from a Single-sized Messenger RNA as a Type I Membrane Glycoprotein1998 •
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes
The Milk fat globule membrane1975 •
Journal of Biological Chemistry
The PRY/SPRY/B30.2 Domain of Butyrophilin 1A1 (BTN1A1) Binds to Xanthine Oxidoreductase: IMPLICATIONS FOR THE FUNCTION OF BTN1A1 IN THE MAMMARY GLAND AND OTHER TISSUES2009 •
International Dairy Journal
Characterization of sheep milk fat globule proteins by two-dimensional polyacrylamide gel electrophoresis/mass spectrometry and generation of a reference map2012 •
Journal of Dairy Research
Identification of lipid synthesis and secretion proteins in bovine milk2014 •
Progress Lipid Res.
The biogenesis and functions of lipid bodies in animals, plants and microorganisms2001 •
International Dairy Journal
Relationship between activity of some fat globule membrane enzymes and the lipidic fraction in ewes' milk: Preliminary studies2010 •
Hangug chugsan sigpum haghoeji = Korean journal for food science of animal resources
Composition, Structure, and Bioactive Components in Milk Fat Globule MembraneInternational Dairy Journal
Milk fat globule size is affected by fat production in dairy cows2004 •
The Journal of Cell Biology
Characterization of an apically derived epithelial membrane glycoprotein from bovine milk, which is expressed in capillary endothelia in diverse tissues1985 •
The Journal of Biological Chemistry
Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation1990 •
Journal of Mammary Gland Biology and Neoplasia
Introduction: Secretory Activation: From the Past to the Future2007 •
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes
The epithelial mucin, MUC1, of milk, mammary gland and other tissues1995 •
Molecular and Cellular Endocrinology
Milk lipid composition is modified by perinatal exposure to bisphenol A2015 •
Journal of Proteomics
Ovine subclinical mastitis: Proteomic analysis of whey and milk fat globules unveils putative diagnostic biomarkers in milk2013 •
2013 •
International Dairy Journal
Nutritional and technological aspects of milk fat globule membrane material2008 •
Journal of Agricultural and Food Chemistry
Lactosomes: Structural and Compositional Classification of Unique Nanometer-Sized Protein Lipid Particles of Human MilkJournal of Agricultural and Food Chemistry
Using Confocal Laser Scanning Microscopy To Probe the Milk Fat Globule Membrane and Associated Proteins2010 •
The American journal of pathology
Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane1985 •
2003 •
Small Ruminant Research
Characterization of size and composition of milk fat globules from Sarda and Saanen dairy goats2013 •
Cell and Tissue Research
Ultrastructural characterization by ruthenium red of the surface of the fat globule membrane of human and rat milk with data on carbohydrates of fractions of rat milk1975 •
The Journal of Immunology
BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell Activation2010 •
European Journal of Biochemistry
Identification and characterization of the principal proteins of the fat-globule membrane from guinea-pig milk1985 •
Journal of Molecular Histology
Cell–Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with β1 Integrin in a 3D Model of Morphogenesis2004 •
Cellular Lipid Metabolism
Receptor-Mediated Endocytosis and Intracellular Trafficking of Lipoproteins2009 •