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2005, Nature Reviews Microbiology
Philosophical Transactions of the Royal Society B: Biological Sciences
Conjugative plasmids: vessels of the communal gene pool2009 •
Microbiology (Reading, England)
Retrotransfer or gene capture: a feature of conjugative plasmids, with ecological and evolutionary significance1999 •
2017 •
Conjugation is a key mechanism of bacterial evolution that involves mobile genetic elements. Recent findings indicated that the main actors of conjugative transfer are not the well-known conjugative or mobilizable plasmids but are the integrated elements. This paper reviews current knowledge on "integrative and mobilizable elements" (IMEs) that have recently been shown to be highly diverse and highly widespread but are still rarely described. IMEs encode their own excision and integration and use the conjugation machinery of unrelated co-resident conjugative element for their own transfer. Recent studies revealed a much more complex and much more diverse lifecycle than initially thought. Besides their main transmission as integrated elements, IMEs probably use plasmid-like strategies to ensure their maintenance after excision. Their interaction with conjugative elements reveals not only harmless hitchhikers but also hunters that use conjugative elements as target for their...
FEMS Microbiology Reviews
Control of genes for conjugative transfer of plasmids and other mobile elements1998 •
FEMS Microbiology Reviews
Dynamics of the IncW genetic backbone imply general trends in conjugative plasmid evolution2006 •
Molecular Biology and Evolution
Host Range and Genetic Plasticity Explain the Coexistence of Integrative and Extrachromosomal Mobile Genetic Elements2018 •
Self-transmissible mobile genetic elements drive horizontal gene transfer between prokaryotes. Some of these elements integrate in the chromosome, whereas others replicate autonomously as plasmids. Recent works showed the existence of few differences, and occasional interconversion, between the two types of elements. Here, we enquired on why evolutionary processes have maintained the two types of mobile genetic elements by comparing integrative and conjugative elements (ICE) with extrachromosomal ones (conjugative plasmids) of the highly abundant MPF T conjugative type. We observed that plasmids encode more replicases, partition systems, and antibiotic resistance genes, whereas ICEs encode more integrases and metabolism-associated genes. ICEs and plasmids have similar average sizes, but plasmids are much more variable, have more DNA repeats, and exchange genes more frequently. On the other hand, we found that ICEs are more frequently transferred between distant taxa. We propose a model where the different genetic plasticity and amplitude of host range between elements explain the co-occurrence of integrative and extrachromosomal elements in microbial populations. In particular, the conversion from ICE to plasmid allows ICE to be more plastic, while the conversion from plasmid to ICE allows the expansion of the element's host range.
2005 •
Frontiers in Bioscience-landmark
Bacterial plasmids: replication of extrachromosomal genetic elements encoding resistance to antimicrobial compounds1999 •
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1986 •
FEMS Microbiology Reviews
Conjugative and mobilizable genomic islands in bacteria: evolution and diversity2014 •
Nucleic Acids Research
ACLAME: A CLAssification of Mobile genetic Elements, update 20102010 •
Nucleic acids research
The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts2014 •
2011 •
Nucleic Acids Research
Novel regulatory mechanism of establishment genes of conjugative plasmids2018 •
Journal of Bacteriology
Genes involved in production of plasmidlike forms by a Bacteroides conjugal chromosomal element share amino acid homology with two-component regulatory systems1992 •
Scientific Reports
Four genes essential for recombination define GInts, a new type of mobile genomic island widespread in bacteria2017 •
2008 •
Journal of Bacteriology
Modular Evolution of TnGBSs, a New Family of Integrative and Conjugative Elements Associating Insertion Sequence Transposition, Plasmid Replication, and Conjugation for Their Spreading2013 •
Cellular and Molecular Life Sciences (CMLS)
Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinants2002 •
Journal of Bacteriology
Entry exclusion of conjugative plasmids of the IncA, IncC and related untyped incompatibility groups2019 •
2000 •
1997 •
Journal of Bacteriology
Characterization of In0 of Pseudomonas aeruginosa plasmid pVS1, an ancestor of integrons of multiresistance plasmids and transposons of gram-negative bacteria1992 •
NAR Genomics and Bioinformatics
pLS20 is the archetype of a new family of conjugative plasmids harboured by Bacillus species2021 •
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Spontaneous transposition in the bacteriophage λ cro gene residing on a plasmid1992 •
Journal of Bacteriology
A Variety of Bacterial Pili Involved in Horizontal Gene Transfer2010 •
Journal of Bacteriology
DNA-Damaging Agents Induce the RecA-Independent Homologous Recombination Functions of Integrating Conjugative Elements of the SXT/R391 Family2013 •
1998 •
Current Biology
A Simple Method for Genome-Wide Screening for Advantageous Insertions of Mobile DNAs in Escherichia coli2002 •
Nature Reviews Microbiology
Studying plasmid horizontal transfer in situ: a critical review2005 •