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Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Microfluidics2013 •
Microfluidics concerns the manipulation of small volumes of fluids (typically nanoliters or less) within networks of channels that have dimensions of tens to hundreds of micrometers. Such devices benefit from having small footprints, low volume requirements of samples and reagents, short analysis times, and a large degree of control over processes being performed, allowing miniaturization of single or multiple laboratory-based procedures and giving rise to ‘lab-on-a-chip’ technology. Microfluidic platforms have become powerful tools in a broad range of fields, from chemistry and engineering to the life sciences, and are revolutionizing the way research can be performed and the quality of information that can be gained.
Micro-technology has played a substantial role in bioscience, biomedical and biotechnological research due to its core advantages in modern science and engineering. It has created unique development in various sectors of bio-research and upsurges the efficacy of research at the molecular level in recent years. Microfluidic technology makes it possible to manipulate sample volumes at the micro- and nano-level (called nanofluidics) with terrific control outside in vivo cellular microenvironment, enabling the reduction of discrepancies between in vivo and in vitro environments as well as reducing reaction time and cost. In this review, we discuss various effective integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bio-research, supporting mechanical and chemical in vitro cellular micro-environment. Specific innovations relating to the application of microfluidics to advance microbial life, solitary and co-cultures along with a multiple-typ...
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2011 •
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