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Review
. 2020 Jul 16;8(3):391.
doi: 10.3390/vaccines8030391.

Human Papillomavirus Vaccines: An Updated Review

Liqin Cheng  1 , Yan Wang  1 , Juan Du  1
Affiliations
Review

Human Papillomavirus Vaccines: An Updated Review

Liqin Cheng et al. Vaccines (Basel). .

Abstract

Human papillomavirus (HPV) vaccines, which were introduced in many countries in the past decade, have shown promising results in decreasing HPV infection and related diseases, such as warts and precancerous lesions. In this review, we present the updated information about current HPV vaccines, focusing on vaccine coverage and efficacy. In addition, pan-gender vaccination and current clinical trials are also discussed. Currently, more efforts should be put into increasing the vaccine's coverage, especially in low- and middle-income countries. Provision of education on HPV and vaccination is one of the most important methods to achieve this. Vaccines that target HPV types not included in current vaccines are the next stage in vaccine development. In the future, all HPV-related cancers, such as head and neck cancer, and anal cancer, should be tracked and evaluated, especially in countries that have introduced pan-gender vaccination programs. Therapeutic vaccines, in combination with other cancer treatments, should continue to be investigated.

Keywords: Cervarix; Gardasil; Gardasil 9; human papillomavirus; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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References

    1. Brianti P., De Flammineis E., Mercuri S.R. Review of HPV-related diseases and cancers. New Microbiol. 2017;40:80–85. - PubMed
    1. Näsman A., Du J., Dalianis T. A global epidemic increase of an HPV-induced tonsil and tongue base cancer—Potential benefit from a pan-gender use of HPV vaccine. J. Intern. Med. 2020;287:134–152. doi: 10.1111/joim.13010. - DOI - PubMed
    1. Leeds I.L., Fang S.H. Anal cancer and intraepithelial neoplasia screening: A review. World J. Gastrointest. Surg. 2016;8:41–51. doi: 10.4240/wjgs.v8.i1.41. - DOI - PMC - PubMed
    1. Tommasino M. The human papillomavirus family and its role in carcinogenesis. Semin. Cancer Biol. 2014;26:13–21. doi: 10.1016/j.semcancer.2013.11.002. - DOI - PubMed
    1. Pastrana D.V., Peretti A., Welch N.L., Borgogna C., Olivero C., Badolato R., Notarangelo L.D., Gariglio M., FitzGerald P.C., McIntosh C.E., et al. Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency. mSphere. 2018;3:e00645-18. doi: 10.1128/mSphereDirect.00645-18. - DOI - PMC - PubMed

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