COVID-19: Mechanisms of Vaccination and Immunity
- PMID: 32707833
- PMCID: PMC7564472
- DOI: 10.3390/vaccines8030404
COVID-19: Mechanisms of Vaccination and Immunity
Abstract
Vaccines are needed to protect from SARS-CoV-2, the virus causing COVID-19. Vaccines that induce large quantities of high affinity virus-neutralizing antibodies may optimally prevent infection and avoid unfavorable effects. Vaccination trials require precise clinical management, complemented with detailed evaluation of safety and immune responses. Here, we review the pros and cons of available vaccine platforms and options to accelerate vaccine development towards the safe immunization of the world's population against SARS-CoV-2. Favorable vaccines, used in well-designed vaccination strategies, may be critical for limiting harm and promoting trust and a long-term return to normal public life and economy.
Keywords: COVID-19; SARS-CoV-2; immunity; nucleic acid tests; serology; vaccination.
Conflict of interest statement
M.F.B. owns shares of Saiba GmbH, which is involved in the development of a vaccine against COVID-19. D.E.S. declares no competing interests.
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References
-
- Salathé M., Althaus C.L., Neher R., Stringhini S., Hodcroft E., Fellay J., Zwahlen M., Senti G., Battegay M., Wilder-Smith A., et al. COVID-19 epidemic in Switzerland: On the importance of testing, contact tracing and isolation. Swiss Med. Wkly. 2020;150:w20225. doi: 10.4414/smw.2020.20225. - DOI - PubMed
-
- Cheng V.C.C., Wong S.-C., Chen J.H.K., Yip C.C.Y., Chuang V.W.M., Tsang O.T.Y., Sridhar S., Chan J.F.W., Ho P.-L., Yuen K.-Y. Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. Infect. Control Hosp. Epidemiol. 2020;41:493–498. doi: 10.1017/ice.2020.58. - DOI - PMC - PubMed
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