We studied radioactive metal compounds to determine their localization in malignant Greene melano... more We studied radioactive metal compounds to determine their localization in malignant Greene melanoma in the eye of the Syrian golden hamsters. Scintigraphy of an ocular melanoma was achieved with several radioactive metals: radioactive (¹¹¹In)-bleomycin, radioactive gallium (â¶â·Ga)-citrate, and radioactive lead (²°³Pb)-tris. The ¹¹¹In-bleomycin had the highest tumor uptake (5.45% dose/g), but not the highest tumor-to-background ratios. The â¶â·Ga-citrate had a
Using the Greene melanoma in the hamster (Syrian Golden), the ; radiopharmaceutical, ¹²³I-4(3-... more Using the Greene melanoma in the hamster (Syrian Golden), the ; radiopharmaceutical, ¹²³I-4(3-dimethylaminopropylamino)- 7-Iodoquinoline, ; was tested for its ability to localize melanoma. This quinoline analog has been ; described for use in the detection of melanoma, but this is the first report, to ; our knowledge, of its being used with an ¹²³I label. Hamsters with either ; skin
... The Medical Research Center (Dr. Packer, Dr. Atkins) and the Chemistry Department (Dr. Lanbre... more ... The Medical Research Center (Dr. Packer, Dr. Atkins) and the Chemistry Department (Dr. Lanbrecht, Dr. Wolf) ... that is, does the agent also go to chorold, retina, bone, blood, muscle, etc. By looking at the tine course of radioactivity In the tumor relative to these ...
Radiotherapy of Choroidal Melanoma with Iodine 125* SAMUEL PACKER MARVIN ROTM AN Radiotherapy of ... more Radiotherapy of Choroidal Melanoma with Iodine 125* SAMUEL PACKER MARVIN ROTM AN Radiotherapy of intraocular tumors has been reported prior to 1930; how- ever, it was Moore, Stallard, and Milner in 1931 [18] and Stallard in 1933 [26] ...
A novel instrument for the noninvasive diagnosis of ocular melanoma was evaluated with 67Ga in pa... more A novel instrument for the noninvasive diagnosis of ocular melanoma was evaluated with 67Ga in patients with pathologically confirmed tumours. The decision to enucleate was based on the results of standard ophthalmic diagnostic modalities including the 32P uptake test. The differences in the ocular radioactivity at 48-72 h predicted the presence of ocular abnormality. A positive differential result was found for tumours having a volume of greater than 600 mm3. Smaller tumours indicated lower retention of 67Ga in the eye with the tumour, whereas control subjects showed less than 2% differences in the radioactivity present in either eye.
We studied radioactive metal compounds to determine their localization in malignant Greene melano... more We studied radioactive metal compounds to determine their localization in malignant Greene melanoma in the eye of the Syrian golden hamsters. Scintigraphy of an ocular melanoma was achieved with several radioactive metals: radioactive (¹¹¹In)-bleomycin, radioactive gallium (â¶â·Ga)-citrate, and radioactive lead (²°³Pb)-tris. The ¹¹¹In-bleomycin had the highest tumor uptake (5.45% dose/g), but not the highest tumor-to-background ratios. The â¶â·Ga-citrate had a
Using the Greene melanoma in the hamster (Syrian Golden), the ; radiopharmaceutical, ¹²³I-4(3-... more Using the Greene melanoma in the hamster (Syrian Golden), the ; radiopharmaceutical, ¹²³I-4(3-dimethylaminopropylamino)- 7-Iodoquinoline, ; was tested for its ability to localize melanoma. This quinoline analog has been ; described for use in the detection of melanoma, but this is the first report, to ; our knowledge, of its being used with an ¹²³I label. Hamsters with either ; skin
... The Medical Research Center (Dr. Packer, Dr. Atkins) and the Chemistry Department (Dr. Lanbre... more ... The Medical Research Center (Dr. Packer, Dr. Atkins) and the Chemistry Department (Dr. Lanbrecht, Dr. Wolf) ... that is, does the agent also go to chorold, retina, bone, blood, muscle, etc. By looking at the tine course of radioactivity In the tumor relative to these ...
Radiotherapy of Choroidal Melanoma with Iodine 125* SAMUEL PACKER MARVIN ROTM AN Radiotherapy of ... more Radiotherapy of Choroidal Melanoma with Iodine 125* SAMUEL PACKER MARVIN ROTM AN Radiotherapy of intraocular tumors has been reported prior to 1930; how- ever, it was Moore, Stallard, and Milner in 1931 [18] and Stallard in 1933 [26] ...
A novel instrument for the noninvasive diagnosis of ocular melanoma was evaluated with 67Ga in pa... more A novel instrument for the noninvasive diagnosis of ocular melanoma was evaluated with 67Ga in patients with pathologically confirmed tumours. The decision to enucleate was based on the results of standard ophthalmic diagnostic modalities including the 32P uptake test. The differences in the ocular radioactivity at 48-72 h predicted the presence of ocular abnormality. A positive differential result was found for tumours having a volume of greater than 600 mm3. Smaller tumours indicated lower retention of 67Ga in the eye with the tumour, whereas control subjects showed less than 2% differences in the radioactivity present in either eye.
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