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→‎Layers, regions and histology: Removed Wheater/Young source as unneeded; I think that source uses the three-layer description. Moved Oxford/Arulkumaran source up in its place (the four-layer description). Moved Wylie WP:REFNAME; WP:CITEKILL.
Replaced wordnetweb.princeton.edu and onlineslangdictionary.com sources in Etymology and definition section. Added reference for acidity. Replaced WebMD, labmed.ucsf.edu sources in the Clinical significance section. Consistent reference formatting.
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==Etymology and definition==
==Etymology and definition==
The term ''vagina'' is from [[Latin]] ''vāgīnae'', literally "sheath" or "[[scabbard]]." It is often referred to as the ''birth canal'' in the context of pregnancy and childbirth, though the term is, by definition, the area between the outside of the vagina and the fully dilated cervix, which is the neck of the uterus.<ref>{{cite web |url=http://wordnetweb.princeton.edu/perl/webwn?s=birth%20canal |title=Princeton University's Wordnet search results for Birth Canal |publisher=Princeton |accessdate=24 May 2010}}</ref>
The term ''vagina'' is from [[Latin]] ''vāgīnae'', literally "sheath" or "[[scabbard]]" is referred to as the ''birth canal'' in the context of pregnancy and childbirth , , the , |url=http://../?= |= |publisher= |accessdate= }}</ref>


Although by its dictionary and anatomical definitions, the term ''vagina'' refers exclusively to the specific internal structure, it is [[Colloquialism|colloquially]] used to refer to the [[vulva]] or to both the vagina and vulva.<ref name="Dalton">{{cite book|author=Maureen Dalton|title=Forensic Gynaecology|publisher=[[Cambridge University Press]]|isbn=1107064295|year=2014|page=65|accessdate=November 29, 2014|url=http://books.google.com/books?id=Kr6ZBAAAQBAJ&pg=PA65}}</ref><ref name="Jones">{{cite book|authors=Therese Jones, Delese Wear, Lester D. Friedman|title=Health Humanities Reader|publisher=[[Rutgers University Press]]|isbn=081357367X|year=2014|pages=231-232|accessdate=November 29, 2014|url=http://books.google.com/books?id=wqRvBAAAQBAJ&pg=PT231}}</ref> Using the term ''vagina'' to mean "vulva" can pose medical or legal confusion; for example, a person's interpretation of its location not matching another person's interpretation of the location.<ref name="Dalton"/> Medically, the vagina is the muscular canal between the [[hymen]] (or remnants of the hymen) and the [[cervix]], while, legally, it begins at the vulva (between the [[labia]]).<ref name="Dalton"/>
The Latinate plural "vaginae" is rarely used in English. [[Colloquialism|Colloquially]], the word ''vagina'' is often used to refer to the [[vulva]] or to the female genitals in general.<ref>[http://onlineslangdictionary.com/thesaurus/words+meaning+vulva+%28%27vagina%27%29,+female+genitalia.html Words meaning vulva ('vagina'), female genitalia] Online Slang Dictionary</ref> However, by its dictionary and anatomical definitions, ''vagina'' refers exclusively to the specific internal structure.


==Structure ==
==Structure ==
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[[File:Vagina (mucosa).JPG|thumb||Medium-power magnification [[micrograph]] of a [[H&E stain]]ed slide showing a portion of a vaginal wall. [[Stratified squamous epithelium]] and underling connective tissue can be seen. The deeper muscular layers are not shown. The black line points to a fold in the mucosa.]]
[[File:Vagina (mucosa).JPG|thumb||Medium-power magnification [[micrograph]] of a [[H&E stain]]ed slide showing a portion of a vaginal wall. [[Stratified squamous epithelium]] and underling connective tissue can be seen. The deeper muscular layers are not shown. The black line points to a fold in the mucosa.]]


The walls of the vagina from the lumen outwards are a [[mucosa]] of non-[[keratin]]ized [[stratified squamous epithelium]] with an underlying [[lamina propria]] of [[connective tissue]], secondly a layer of [[smooth muscle]] with bundles of circular fibers on the inside and longitudinal fibers on the outside and thirdly an outer layer of connective tissue called (tunica) [[adventitia]]. Some sources distinguish four layers by counting both the mucosa's epithelium and lamina propria sublayers.<ref name="Brown">{{cite book|last=Brown|first=Laurence|title=Pathology of the Vulva and Vagina|accessdate=February 21, 2014|year=2012|publisher=[[Springer Science+Business Media]]|isbn=0857297570|pages=6–7|url=http://books.google.com/books?id=Yv2CMHoVR9wC&pg=PA6}}</ref><ref name="Arulkumaran">{{cite book|authors=Sabaratnam Arulkumaran, Lesley Regan, Aris Papageorghiou, Ash Monga, David Farquharson|title=Oxford Desk Reference: Obstetrics and Gynaecology|accessdate=February 21, 2014|year=2011|publisher=[[Oxford University Press]]|isbn=0191620874|page=471|url=http://books.google.com/books?id=lRaWcRYx_7YC&pg=PA471}}</ref> The epithelium forms folds or [[rugae]] and facilitate the vagina's ability to expand large enough for [[childbirth]]. The rugae are a series of ridges produced by folding of the wall of the outer third of the vagina; they are transverse epithelial ridges and their function is to provide the vagina with increased surface area for extension and stretching. The lamina propria is under [[Basement membrane|the base area]] lining the epithelium, and is rich in blood vessels and lymphatic channels. Beneath the lamina propria is the [[muscular layer]], which is composed of smooth muscle fibers, with an outer layer of longitudinal muscle, and an inner layer of circular muscle. The final layer, the adventitia, is a dense connective tissue that blends with the [[fascia]] surrounding the area, and contains blood vessels, [[lymphatic vessel]]s and nerve fibers.<ref name="Mulhall"/><ref name="Arulkumaran"/><ref name="Wylie">{{cite book|last=Wylie|first=Linda|title=Essential Anatomy and Physiology in Maternity Care|accessdate=19 February 2014|year=2005|publisher=Elsevier Health Sciences|isbn=0-443-10041-1|pages=157–158|url=http://books.google.com/books?id=QgpOvSDxGGYC&pg=PA157}}</ref>
The walls of the vagina from the lumen outwards are a [[mucosa]] of non-[[keratin]]ized [[stratified squamous epithelium]] with an underlying [[lamina propria]] of [[connective tissue]], secondly a layer of [[smooth muscle]] with bundles of circular fibers on the inside and longitudinal fibers on the outside and thirdly an outer layer of connective tissue called (tunica) [[adventitia]]. Some sources distinguish four layers by counting both the mucosa's epithelium and lamina propria sublayers.<ref name="Brown">{{cite book|last=Brown|first=Laurence|title=Pathology of the Vulva and Vagina|accessdate=February 21, 2014|year=2012|publisher=[[Springer Science+Business Media]]|isbn=0857297570|pages=6–7|url=http://books.google.com/books?id=Yv2CMHoVR9wC&pg=PA6}}</ref><ref name="Arulkumaran">{{cite book|authors=Sabaratnam Arulkumaran, Lesley Regan, Aris Papageorghiou, Ash Monga, David Farquharson|title=Oxford Desk Reference: Obstetrics and Gynaecology|accessdate=February 21, 2014|year=2011|publisher=[[Oxford University Press]]|isbn=0191620874|page=471|url=http://books.google.com/books?id=lRaWcRYx_7YC&pg=PA471}}</ref> The epithelium forms folds or [[rugae]] and facilitate the vagina's ability to expand large enough for childbirth. The rugae are a series of ridges produced by folding of the wall of the outer third of the vagina; they are transverse epithelial ridges and their function is to provide the vagina with increased surface area for extension and stretching. The lamina propria is under [[Basement membrane|the base area]] lining the epithelium, and is rich in blood vessels and lymphatic channels. Beneath the lamina propria is the [[muscular layer]], which is composed of smooth muscle fibers, with an outer layer of longitudinal muscle, and an inner layer of circular muscle. The final layer, the adventitia, is a dense connective tissue that blends with the [[fascia]] surrounding the area, and contains blood vessels, [[lymphatic vessel]]s and nerve fibers.<ref name="Mulhall"/><ref name="Arulkumaran"/><ref name="Wylie">{{cite book|last=Wylie|first=Linda|title=Essential Anatomy and Physiology in Maternity Care|accessdate=19 February 2014|year=2005|publisher=Elsevier Health Sciences|isbn=0-443-10041-1|pages=157–158|url=http://books.google.com/books?id=QgpOvSDxGGYC&pg=PA157}}</ref>
[[File:Rugae vaginales.jpg|thumb|upright|Folds of mucosa (or vaginal rugae) are shown in the front third of a vagina]]
[[File:Rugae vaginales.jpg|thumb|upright|Folds of mucosa (or vaginal rugae) are shown in the front third of a vagina]]
[[File:Cervix.jpg|thumb|A normal [[cervix]] of an adult as seen through the vagina (per vaginam or PV) using a [[Speculum (medical)#Vaginal use|bivalved vaginal speculum]]. The blades of the speculum are above and below and stretched vaginal walls are seen on the left and right]]
[[File:Cervix.jpg|thumb|A normal [[cervix]] of an adult as seen through the vagina (per vaginam or PV) using a [[Speculum (medical)#Vaginal use|bivalved vaginal speculum]]. The blades of the speculum are above and below and stretched vaginal walls are seen on the left and right]]
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The vaginal opening (or orifice) is at the [[Caudal (anatomical term)|caudal]] end of the vulva, behind the opening of the urethra, resting at the posterior end of the vestibule. It is closed by the labia minora in female virgins and in females who have never given birth ([[Gravidity and parity|nulliparae]]), but may be exposed in females who have given birth (parous females).<ref name="Dutta"/>
The vaginal opening (or orifice) is at the [[Caudal (anatomical term)|caudal]] end of the vulva, behind the opening of the urethra, resting at the posterior end of the vestibule. It is closed by the labia minora in female virgins and in females who have never given birth ([[Gravidity and parity|nulliparae]]), but may be exposed in females who have given birth (parous females).<ref name="Dutta"/>


The [[hymen]] is a [[membrane]] of tissue that surrounds or partially covers the vaginal opening.<ref name="Dutta"/> The effects of vaginal intercourse and childbirth on the hymen are variable. If the hymen is sufficiently elastic, it may return to nearly its original condition. In other cases, there may be remnants (carunculae myrtiformes), or it may appear completely absent after repeated penetration.<ref name="Jacoby">{{cite book|last1=Jacoby|first1=David B.|last2=Youngson|first2=Robert M.|title=Encyclopedia of Family Health|edition=3rd|year=2005|publisher=Marshall Cavendish|isbn=0-7614-7486-2|page=889}}</ref><ref name="Knight">{{cite book|last=Knight|first=Bernard|title=Simpson's Forensic Medicine|edition=11th|year=1997|publisher=Arnold|location=London|page=114|isbn=0-7131-4452-1}}</ref> Additionally, the hymen may be lacerated by disease, injury, medical examination, [[masturbation]] or physical exercise. For these reasons, it is not possible to definitively determine whether or not a girl or woman is a [[virginity|virgin]] by examining her hymen.<ref name="Jacoby"/><ref name="Knight"/><ref name="Perlman">{{Cite book|last=Perlman|first=Sally E. |coauthors=Nakajyma, Steven T. and Hertweck, S. Paige |title=Clinical protocols in pediatric and adolescent gynecology|year=2004|publisher=Parthenon |page=131 |isbn=1-84214-199-6 }}</ref>
The hymen is a [[membrane]] of tissue that surrounds or partially covers the vaginal opening.<ref name="Dutta"/> The effects of vaginal intercourse and childbirth on the hymen are variable. If the hymen is sufficiently elastic, it may return to nearly its original condition. In other cases, there may be remnants (carunculae myrtiformes), or it may appear completely absent after repeated penetration.<ref name="Jacoby">{{cite book|last1=Jacoby|first1=David B.|last2=Youngson|first2=Robert M.|title=Encyclopedia of Family Health|edition=3rd|year=2005|publisher=Marshall Cavendish|isbn=0-7614-7486-2|page=889}}</ref><ref name="Knight">{{cite book|last=Knight|first=Bernard|title=Simpson's Forensic Medicine|edition=11th|year=1997|publisher=Arnold|location=London|page=114|isbn=0-7131-4452-1}}</ref> Additionally, the hymen may be lacerated by disease, injury, medical examination, [[masturbation]] or physical exercise. For these reasons, it is not possible to definitively determine whether or not a girl or woman is a [[virginity|virgin]] by examining her hymen.<ref name="Jacoby"/><ref name="Knight"/><ref name="Perlman">{{Cite book|last=Perlman|first=Sally E. |coauthors=Nakajyma, Steven T. and Hertweck, S. Paige |title=Clinical protocols in pediatric and adolescent gynecology|year=2004|publisher=Parthenon |page=131 |isbn=1-84214-199-6 }}</ref>


===Variations and size===
===Variations and size===
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{{Main|Vaginal flora}}
{{Main|Vaginal flora}}


The vagina is a nutrient rich environment that harbors a unique and complex [[microbiome]]. It is a dynamic ecosystem that undergoes long term changes, from neonate to puberty and from the reproductive period (menarche) to menopause. Moreover, under the influence of hormones, such as estrogen (estradiol), progesterone and follicle stimulating hormone (FSH), the vaginal ecosystem undergoes cyclic or periodic changes, i.e. during menses and pregnancy.<ref name="Danielsson">Danielsson, D., P. K. Teigen, and H. Moi. 2011. The genital econiche: Focus on microbiota and bacterial vaginosis" ''Ann. N. Y. Acad. Sci'' 1230:48-58</ref> One significant variable parameter is the vaginal pH, which varies significantly during a woman‘s lifespan, from 7.0 in premenarchal girls, to 3.8-4.4 in women of reproductive age to 6.5-7.0 during menopause without hormone therapy and 4.5-5.0 with hormone replacement therapy.<ref name="Danielsson" /> Estrogen, glycogen and lactobacilli are important factors in this variation.<ref name="Danielsson" />
The vagina is a nutrient rich environment that harbors a unique and complex [[microbiome]]. It is a dynamic ecosystem that undergoes long term changes, from neonate to puberty and from the reproductive period (menarche) to menopause. Moreover, under the influence of hormones, such as estrogen (estradiol), progesterone and follicle stimulating hormone (FSH), the vaginal ecosystem undergoes cyclic or periodic changes, i.e. during menses and pregnancy.<ref name=""> . , . ..</ref> One significant variable parameter is the vaginal pH, which varies significantly during a lifespan, from 7.0 in premenarchal girls, to 3.8-4.4 in women of reproductive age to 6.5-7.0 during menopause without hormone therapy and 4.5-5.0 with hormone replacement therapy.<ref name="Danielsson" /> Estrogen, glycogen and lactobacilli are important factors in this variation.<ref name="Danielsson" />


== Clinical significance ==
== Clinical significance ==
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The vagina is self-cleansing and therefore usually needs no special treatment. To maintain [[vulvovaginal health]], doctors generally discourage the practice of [[douche|douching]].<ref name="Grimes">{{cite book|authors=Jill Ann Grimes, Lori Apffel Smith, Kristyn Fagerberg|title=Sexually Transmitted Disease: An Encyclopedia of Diseases, Prevention, Treatment, and Issues [2 volumes]: An Encyclopedia of Diseases, Prevention, Treatment, and Issues|publisher=[[ABC-CLIO]]|isbn=1440801355|year=2013|pages=590-592|accessdate=November 22, 2014|url=http://books.google.com/books?id=wagNAgAAQBAJ&pg=PA590}}</ref> Since a healthy vagina is colonized by a mutually [[symbiotic]] flora of microorganisms that protect its host from disease-causing microbes, any attempt to upset this balance may cause many undesirable outcomes, including but not limited to abnormal discharge and [[yeast infection]].<ref name="Grimes"/>
The vagina is self-cleansing and therefore usually needs no special treatment. To maintain [[vulvovaginal health]], doctors generally discourage the practice of [[douche|douching]].<ref name="Grimes">{{cite book|authors=Jill Ann Grimes, Lori Apffel Smith, Kristyn Fagerberg|title=Sexually Transmitted Disease: An Encyclopedia of Diseases, Prevention, Treatment, and Issues [2 volumes]: An Encyclopedia of Diseases, Prevention, Treatment, and Issues|publisher=[[ABC-CLIO]]|isbn=1440801355|year=2013|pages=590-592|accessdate=November 22, 2014|url=http://books.google.com/books?id=wagNAgAAQBAJ&pg=PA590}}</ref> Since a healthy vagina is colonized by a mutually [[symbiotic]] flora of microorganisms that protect its host from disease-causing microbes, any attempt to upset this balance may cause many undesirable outcomes, including but not limited to abnormal discharge and [[yeast infection]].<ref name="Grimes"/>


The vagina and cervix are examined during [[gynaecology|gynecological]] examinations of the pelvis, often using a [[speculum (medical)|speculum]], which holds the vagina open for visual inspection or taking samples (see [[pap smear]]).<ref name="Vickery">{{cite book|authors=Donald M. Vickery, James F. Fries|title=Take Care of Yourself: The Complete Illustrated Guide to Medical Self-Care|publisher=[[Da Capo Press]]|isbn=0786752181|year=2013|pages=427-428|accessdate=November 22, 2014|url=http://books.google.com/books?id=dXqEAAAAQBAJ&pg=PT427}}</ref><ref name="WebMD Vagina">{{cite web|title=The Vagina (Human Anatomy)|publisher=[[WebMD]]|accessdate=April 27, 2014|url=http://www.webmd.com/women/picture-of-the-vagina}}</ref> This and other [[medical procedure]]s involving the vagina, including digital internal examinations and administration of medicine,<ref name="Vickery"/><ref name=AW2007>See, e.g., Colin Hinrichsen, Peter Lisowski, ''Anatomy Workbook'' (2007), p. 101: "Digital examination per vaginam are made by placing one or two fingers in the vagina".</ref> are referred to as being "per vaginam", the Latin for "via the vagina",<ref>{{cite book|title=Mosby's Medical, Nursing & Allied Health Dictionary |editor-first=Douglas M |editor-last=Anderson |isbn=0-7234-3225-2 |edition=6th UK| year=2002 | publisher=Mosby |location=St. Louis, Missouri, USA |page=1324}}</ref> often abbreviated to "p.v.".<ref name=AW2007/>
The vagina and cervix are examined during [[gynaecology|gynecological]] examinations of the pelvis, often using a [[speculum (medical)|speculum]], which holds the vagina open for visual inspection or taking samples (see [[pap smear]]).<ref name="Vickery">{{cite book|authors=Donald M. Vickery, James F. Fries|title=Take Care of Yourself: The Complete Illustrated Guide to Medical Self-Care|publisher=[[Da Capo Press]]|isbn=0786752181|year=2013|pages=427-428|accessdate=November 22, 2014|url=http://books.google.com/books?id=dXqEAAAAQBAJ&pg=PT427}}</ref> This and other [[medical procedure]]s involving the vagina, including digital internal examinations and administration of medicine,<ref name="Vickery"/><ref name=AW2007> Colin Hinrichsen, Peter LisowskiAnatomy Workbook () 101:Digital examination per vaginam are made by placing one or two fingers in the vagina.</ref> are referred to as being "per vaginam", the Latin for "via the vagina",<ref>{{cite book|title=Mosby's Medical, Nursing & Allied Health Dictionary |editor-first=Douglas M |editor-last=Anderson |isbn=0-7234-3225-2 |edition=6th UK| year=2002 | publisher=Mosby |location=St. Louis, Missouri, USA |page=1324}}</ref> often abbreviated to "p.v.".<ref name=AW2007/>
[[File:Spéculum en plastique.jpg|thumb|right|A disposable plastic bi-valved vaginal [[Speculum (medical)|speculum]] used in [[Pelvic examination|gynecological examination]]]]
[[File:Spéculum en plastique.jpg|thumb|right|A disposable plastic bi-valved vaginal [[Speculum (medical)|speculum]] used in [[Pelvic examination|gynecological examination]]]]
The healthy vagina of a woman of child-bearing age is [[acid]]ic, with a [[pH]] normally ranging between 3.8 and 4.5.<ref name="Nassos2009">[http://labmed.ucsf.edu/sfghlab/test/pdf%5CpH_Vaginal_Test_POLICY.pdf Vaginal pH Test] from ''Point of Care Testing'', July 2009, at: University of California, San Francisco&nbsp;– Department of Laboratory Medicine. Prepared by: Patricia Nassos, PhD, MT and Clayton Hooper, RN.</ref> This is due to the degradation of glycogen to the [[lactic acid]] by enzymes secreted by the [[Lactobacillus gasseri|Döderlein's bacillus]]. This is a normal [[commensal]] of the vagina. The acidity retards the growth of many strains of [[pathogen]]ic microbes.<ref>{{cite web|url=http://www.textbookofbacteriology.net/NHPR.html|title=The Nature of Bacterial Host-Parasite Relationships in Humans|work=Online Textbook of Bacteriology|last=Todar|first=Kenneth|year=2008|accessdate=2009-08-28}}</ref> An increased pH of the vagina (with a commonly used [[Cutoff (reference value)|cut-off]] of pH 4.5 or higher) can be caused by bacterial overgrowth, as occurs in [[bacterial vaginosis]] and trichomoniasis, or [[rupture of membranes]] in pregnancy.<ref name="Nassos2009" />
The healthy vagina of a woman of child-bearing age is [[acid]]ic, with a [[pH]] normally ranging between 3.8 and 4.5., and is due to the degradation of glycogen to the [[lactic acid]] by enzymes secreted by the [[Lactobacillus gasseri|Döderlein's bacillus]] is a normal [[commensal]] of the vagina. The acidity retards the growth of many strains of [[pathogen]]ic microbes.<ref>{{cite web|url=http://www.textbookofbacteriology.net/NHPR.html|title=The Nature of Bacterial Host-Parasite Relationships in Humans|work=Online Textbook of Bacteriology|last=Todar|first=Kenneth|year=2008|accessdate=2009-08-28}}</ref> An increased pH of the vagina (with a commonly used [[Cutoff (reference value)|cut-off]] of pH 4.5 or higher) can be caused by bacterial overgrowth, as occurs in [[bacterial vaginosis]] and trichomoniasis, or rupture of membranes in pregnancy.<ref name="" />


[[Intravaginal administration]] is a [[route of administration]] where the substance is applied to the inside of the vagina. [[Pharmacological]]ly, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the [[vaginal portion of cervix]]) with limited systemic [[adverse effect]]s compared to other routes of administration.<ref name="Ranade">{{cite book|authors=Vasant V. Ranade, John B. Cannon|title=Drug Delivery Systems, Third Edition|publisher=[[CRC Press]]|isbn=1439806187|year=2011|page=337|accessdate=November 22, 2014|url=http://books.google.com/books?id=PBfLKBTQk0cC&pg=PA337}}</ref><ref name="Lehne">{{cite book|authors=Richard A. Lehne, Laura Rosenthal|title=Pharmacology for Nursing Care|publisher=[[Elsevier Health Sciences]]|isbn=0323293549|year=2014|page=1146|accessdate=November 22, 2014|url=http://books.google.com/books?id=udTsAwAAQBAJ&pg=PA1146}}</ref>
[[Intravaginal administration]] is a [[route of administration]] where the substance is applied to the inside of the vagina. [[Pharmacological]]ly, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the [[vaginal portion of cervix]]) with limited systemic [[adverse effect]]s compared to other routes of administration.<ref name="Ranade">{{cite book|authors=Vasant V. Ranade, John B. Cannon|title=Drug Delivery Systems, Third Edition|publisher=[[CRC Press]]|isbn=1439806187|year=2011|page=337|accessdate=November 22, 2014|url=http://books.google.com/books?id=PBfLKBTQk0cC&pg=PA337}}</ref><ref name="Lehne">{{cite book|authors=Richard A. Lehne, Laura Rosenthal|title=Pharmacology for Nursing Care|publisher=[[Elsevier Health Sciences]]|isbn=0323293549|year=2014|page=1146|accessdate=November 22, 2014|url=http://books.google.com/books?id=udTsAwAAQBAJ&pg=PA1146}}</ref>

===Diseases===
===Diseases===
{{Main|Vaginal disease}}
{{Main|Vaginal disease}}
Diseases that can affect the vagina include [[Sexually transmitted disease|sexually transmitted infections]] (STIs/STDs) such as [[HIV/AIDS]], [[human papillomavirus]] (HPV), [[genital herpes]], or [[trichomoniasis]], or other infections such as [[candidal vulvovaginitis]]. Because of STIs, health authorities and other health outlets recommend [[safe sex]] practices when engaging in sexual activity.<ref name="Hales"/><ref name="Alexander"/><ref name="WebMD Vagina"/> [[Vaginitis]] is an inflammation of the vagina, and is attributed to several vaginal diseases. By contrast, [[vaginismus]] is an involuntary tightening of the vagina muscles caused by a [[conditioned reflex]], or to disease conditions in the area, during vaginal penetration.<ref name="WebMD Vagina"/>
Diseases that can affect the vagina include [[Sexually transmitted disease|sexually transmitted infections]] (STIs/STDs) such as [[HIV/AIDS]], [[human papillomavirus]] (HPV), [[genital herpes]], or [[trichomoniasis]], or other infections such as [[candidal vulvovaginitis]]. Because of STIs, health authorities and other health outlets recommend [[safe sex]] practices when engaging in sexual activity.<ref name="Hales"/><ref name="Alexander"/> [[Vaginitis]] is an inflammation of the vagina, and is attributed to several vaginal diseases [[vaginismus]] is an involuntary tightening of the vagina muscles caused by a [[conditioned reflex]], or to disease conditions in the area, during vaginal penetration.<ref name=""/>


There can be a vaginal obstruction, such as by [[imperforate hymen]] or, less commonly, a [[transverse vaginal septum]]. Where a lump is present in the vagina, it is most commonly a [[Bartholin's cyst]].<ref>{{cite web|url=http://www.riversideonline.com/health_reference/Womens-Health/DS00667.cfm?RenderForPrint=1 |title=Bartholin cyst |publisher=[[Mayo Clinic]].com |date=19 January 2010 |accessdate=2011-08-18}}</ref> [[Vaginal prolapse]] is characterized by a portion of the [[vaginal canal]] protruding ([[Prolapse|prolapsing]]) from the opening of the vagina. It may result in the case of weakened pelvic muscles, which is a common result of childbirth; in the case of this prolapse, the rectum, uterus, or bladder pushes on the vagina, and severe cases result in the vagina protruding out of the body.<ref name="WebMD Vagina"/> [[Kegel exercise]]s have been used to strengthen the [[pelvic floor]], and may help prevent or remedy vaginal prolapse.<ref name="WebMD Vagina"/><ref name="pmid22161382">{{cite journal |author=Hagen S, Stark D |title=Conservative prevention and management of pelvic organ prolapse in women |journal=Cochrane Database Syst Rev |volume=12 |issue= |pages=CD003882 |year=2011 |pmid=22161382 |doi=10.1002/14651858.CD003882.pub4}}</ref> [[Cervical cancer]] may be prevented by pap smear screening and [[HPV vaccine]]s. [[Vaginal cancer]] is very rare, but its symptoms include abnormal [[vaginal bleeding]] or [[vaginal discharge]].<ref name="WebMD Vagina"/>
There can be a vaginal obstruction, such as by [[imperforate hymen]] or, less commonly, a [[transverse vaginal septum]]. Where a lump is present in the vagina, it is most commonly a [[Bartholin's cyst]].<ref>{{cite web|url=http://www.riversideonline.com/health_reference/Womens-Health/DS00667.cfm?RenderForPrint=1 |title=Bartholin cyst |publisher=[[Mayo Clinic]].com |date=19 January 2010 |accessdate=2011-08-18}}</ref> [[Vaginal prolapse]] is characterized by a portion of the [[vaginal canal]] protruding ([[Prolapse|prolapsing]]) from the opening of the vagina. It may result in the case of weakened pelvic muscles, which is a common result of childbirth; in the case of this prolapse, the rectum, uterus, or bladder pushes on the vagina, and severe cases result in the vagina protruding out of the body. [[Kegel exercise]]s have been used to strengthen the [[pelvic floor]], and may help prevent or remedy vaginal prolapse.<ref name="pmid22161382">{{cite journal |author=Hagen S, Stark D |title=Conservative prevention and management of pelvic organ prolapse in women |journal=Cochrane Database Syst Rev |volume=12 |issue= |pages=CD003882 |year=2011 |pmid=22161382 |doi=10.1002/14651858.CD003882.pub4}}</ref> [[Cervical cancer]] may be prevented by pap smear screening and [[HPV vaccine]]s. [[Vaginal cancer]] is very rare, its symptoms include abnormal [[vaginal bleeding]] or [[vaginal discharge]].<ref name=" "/>


===Modification===
===Modification===

Revision as of 20:13, 29 November 2014

Vagina
Diagram of the female human reproductive tract and ovaries
Vulva with vaginal opening

1: Clitoral hood
2: Clitoris
3: Labium minorum (synonym: labium minus)
4: Urethral opening
5: Vaginal opening
6: Perineum
7: Anus

.
Details
Precursorurogenital sinus and paramesonephric ducts
Arterysuperior part to uterine artery, middle and inferior parts to vaginal artery
Veinuterovaginal venous plexus, vaginal vein
NerveSympathetic: lumbar splanchnic plexus
Parasympathetic: pelvic splanchnic plexus
Lymphupper part to internal iliac lymph nodes, lower part to superficial inguinal lymph nodes
Identifiers
LatinVagina
MeSHD014621
TA98A09.1.04.001
TA23523
FMA19949
Anatomical terminology

The vagina is a fibromuscular tubular sex organ that is part of the female genital tract. In humans, the vagina extends from the vulva to the uterus. At the vulva, the vaginal orifice may be partly covered by a membrane called the hymen, while, at the deep end, the cervix (neck of the uterus) bulges through the anterior wall of the vagina. The vagina facilitates sexual intercourse and childbirth. It also channels the menstrual flow, consisting of blood and pieces of mucosal tissue, that occurs periodically with the shedding of lining of the uterus in menstrual cycles.

The location and structure of the vagina varies among species, and may vary in size within the same species. Unlike mammalian males, who usually have the urethral orifice as the sole external urogenital orifice, mammalian females usually have two external orifices, the urethral orifice for the urological tract and the vaginal orifice for the genital tract. The vaginal orifice is much larger than the nearby urethral opening, and both openings are protected by the labia in humans.[1] In amphibians, birds, reptiles and monotremes, an opening called the cloaca functions as a single external orifice for the gastrointestinal tract, urological tract, and reproductive tract.

The vagina plays a significant role in human female sexuality and sexual pleasure. During sexual arousal for humans and other animals, vaginal moisture increases by way of vaginal lubrication, to reduce friction and allow for smoother penetration of the vagina during sexual activity. The texture of the vaginal walls can create friction for the penis during sexual intercourse and stimulate it toward ejaculation, enabling fertilization.[2] In addition, a variety of sexually transmitted infections (STIs/STDs) and other disorders can affect the vagina. Because of the risk of STIs/STDs, health authorities, such as the World Health Organization (WHO), and health care providers, recommend safe sex practices.[3][4][5]

Cultural perceptions of the vagina have persisted throughout history, ranging from viewing the vagina as the focus of sexual desire, a metaphor for life via birth, inferior to the penis, or as visually unappealing or otherwise vulgar. Colloquially, the word vagina is often used incorrectly to refer to the vulva.

Etymology and definition

The term vagina is from Latin vāgīnae, literally "sheath" or "scabbard"; the Latinate plural of vagina is vaginae,[6] and the term vagina may be referred to as the birth canal in the context of pregnancy and childbirth.[7][8]

Although by its dictionary and anatomical definitions, the term vagina refers exclusively to the specific internal structure, it is colloquially used to refer to the vulva or to both the vagina and vulva.[9][10] Using the term vagina to mean "vulva" can pose medical or legal confusion; for example, a person's interpretation of its location not matching another person's interpretation of the location.[9] Medically, the vagina is the muscular canal between the hymen (or remnants of the hymen) and the cervix, while, legally, it begins at the vulva (between the labia).[9]

Structure

Development and general structure

A precursor to the inferior portion of the vagina, called the vaginal plate, is the growth of tissue that gives rise to the formation of the vagina; it is located where the solid tips of the paramesonephric ducts (Müllerian ducts) enter the dorsal wall of the urogenital sinus as the Müllerian tubercle. The plate's growth is unrestrained, as it significantly separates the cervix and the urogenital sinus; eventually, the central cells of the plate break down to form the vaginal lumen.[11] Until twenty to twenty-four weeks of pregnancy, the vagina is not fully canalized. If it fails to fully canalize, this may result in various forms of septae, which cause obstruction of the outflow tract later in life.[11]

In the absence of testosterone during sexual differentiation (sex development of the differences between males and females), the urogenital sinus persists as the vestibule of the vagina, the two urogenital folds (elongated spindle-shaped structures that contribute to the formation of the urethral groove on the belly aspect of the genital tubercle) form the labia minora, and the labioscrotal swellings enlarge to form the labia majora.[12][13]

There exists debate as to which portion of the vagina is formed from the Müllerian ducts and which from the urogenital sinus by the growth of the sinovaginal bulb.[11][14] Dewhurst's Textbook of Obstetrics and Gynaecology states, "Some believe that the upper four-fifths of the vagina is formed by the Müllerian duct and the lower fifth by the urogenital sinus, while others believe that sinus upgrowth extends to the cervix displacing the Müllerian component completely and the vagina is thus derived wholly from the endoderm of the urogenital sinus." It adds, "It seems certain that some of the vagina is derived from the urogenital sinus, but it has not been determined whether or not the Müllerian component is involved."[11]

The human vagina is an elastic muscular canal that extends from the vulva to the uterus.[15][16] It, along with the inside of the vulva, is reddish pink in color, and it connects the superficial vulva to the cervix of the deep uterus. The vagina is posterior to the urethra and bladder, and reaches across the perineum superiorly and posteriorly toward the cervix; at approximately a 90 degree angle, the cervix protrudes into the vagina.[17]

Layers, regions and histology

An illustration showing a cut-away portion of the vagina and upper female genital tract (only one ovary and fallopian tube shown). Circular folds (also called rugae) of vaginal mucosa can be seen
Medium-power magnification micrograph of a H&E stained slide showing a portion of a vaginal wall. Stratified squamous epithelium and underling connective tissue can be seen. The deeper muscular layers are not shown. The black line points to a fold in the mucosa.

The walls of the vagina from the lumen outwards are a mucosa of non-keratinized stratified squamous epithelium with an underlying lamina propria of connective tissue, secondly a layer of smooth muscle with bundles of circular fibers on the inside and longitudinal fibers on the outside and thirdly an outer layer of connective tissue called (tunica) adventitia. Some sources distinguish four layers by counting both the mucosa's epithelium and lamina propria sublayers.[18][19] The epithelium forms folds or rugae and facilitate the vagina's ability to expand large enough for childbirth. The rugae are a series of ridges produced by folding of the wall of the outer third of the vagina; they are transverse epithelial ridges and their function is to provide the vagina with increased surface area for extension and stretching. The lamina propria is under the base area lining the epithelium, and is rich in blood vessels and lymphatic channels. Beneath the lamina propria is the muscular layer, which is composed of smooth muscle fibers, with an outer layer of longitudinal muscle, and an inner layer of circular muscle. The final layer, the adventitia, is a dense connective tissue that blends with the fascia surrounding the area, and contains blood vessels, lymphatic vessels and nerve fibers.[17][19][20]

Folds of mucosa (or vaginal rugae) are shown in the front third of a vagina
A normal cervix of an adult as seen through the vagina (per vaginam or PV) using a bivalved vaginal speculum. The blades of the speculum are above and below and stretched vaginal walls are seen on the left and right

Where the vaginal lumen surrounds the cervix of the uterus, it is divided into four regions of fornices (the vaginal fornix); these are the anterior, posterior, and the right lateral and left lateral (the lateral fornix).[15][16] The posterior is deeper and the anterior is shallow.[16] While the anterior and posterior walls are placed together, the lateral walls, especially their middle area, are relatively more rigid; because of this, they vagina has a H-shaped cross section.[16] Behind, the upper one-fourth of the vagina is separated from the rectum by the recto-uterine pouch. Superficially, in-front of the pubic bone, a cushion of fat called the mons pubis forms the uppermost part of the vulva.

Supporting the vagina are its upper third, middle third and lower third. The upper third are the levator ani muscles (transcervical, pubocervical) and the sacrocervical ligaments; these areas are also described as the cardinal ligaments laterally and uterosacral ligaments posterolaterally. The middle third of the vagina concerns the urogenital diaphragm (also described as the paracolpos and pelvic diaphragm). The lower third is the perineal body; it may be described as containing the perineal body, pelvic diaphragm and urogenital diaphragm.[15][21]

The epithelial covering of the cervix is continuous with the epithelial lining of the vagina. The vaginal mucosa is absent of glands. The vaginal epithelium consists of three rather arbitrary layers of cells[22]  – superficial flat cells, intermediate cells and basal cells  – and estrogen induces the intermediate and superficial cells to fill with glycogen. The superficial cells exfoliate continuously and basal cells replace them.[16][23][24] Under the influence of maternal estrogen, newborn females have a thick stratified squamous epithelium for two to four weeks after birth. After that, the epithelium remains thin with only a few layers of cells without glycogen until puberty, when the epithelium thickens and glycogen containing cells are formed again, under the influence of the girl's rising estrogen levels. Finally, the epithelium thins out during menopause onward and eventually ceases to contain glycogen, because of the lack of estrogen.[16][24][25] In abnormal circumstances, such as in pelvic organ prolapse, the vaginal epithelium may be exposed becoming dry and keratinized.[26]

For blood and nerve supply, relevant arteries are the cervicovaginal (the uterine cervix and the vagina) branch of the uterine artery, the vaginal artery, middle rectal artery, and the internal pudendal artery. The veins are connected by anastomosis (the connection of separate parts of a branching system to form a network), resulting in the formation of the anterior and posterior azygos (unpaired) arteries. The nerve supply of the vagina is provided by the sympathetic and parasympathetic areas of the pelvic plexus, with the pudendal nerve supplying the lower area.[16]

Vaginal opening and hymen

The vaginal opening (or orifice) is at the caudal end of the vulva, behind the opening of the urethra, resting at the posterior end of the vestibule. It is closed by the labia minora in female virgins and in females who have never given birth (nulliparae), but may be exposed in females who have given birth (parous females).[16]

The hymen is a membrane of tissue that surrounds or partially covers the vaginal opening.[16] The effects of vaginal intercourse and childbirth on the hymen are variable. If the hymen is sufficiently elastic, it may return to nearly its original condition. In other cases, there may be remnants (carunculae myrtiformes), or it may appear completely absent after repeated penetration.[2][27] Additionally, the hymen may be lacerated by disease, injury, medical examination, masturbation or physical exercise. For these reasons, it is not possible to definitively determine whether or not a girl or woman is a virgin by examining her hymen.[2][27][28]

Variations and size

In its normal state, there is anatomical variation in the length of the vagina of a woman of child-bearing age. The length is approximately 7.5 cm (2.5 to 3 in) across the anterior wall (front), and 9 cm (3.5 in) long across the posterior wall (rear), making the posterior fornix deeper than the anterior.[16][20] During sexual arousal, the vagina expands in both length and width.

If a woman stands upright, the vaginal tube points in an upward-backward direction and forms an angle of approximately 45 degrees with the uterus and of about 60 degrees to the horizontal.[16][21]

Pelvic anatomy including organs of the female reproductive system

The vaginal opening and hymen can vary in size; in children, although a common appearance of the hymen is crescent-shaped, many shapes are possible.[16][29]

Function

Secretions

The vagina provides a path for menstrual blood and tissue to leave the body. In industrial societies, tampons, menstrual cups and sanitary napkins may be used to absorb or capture these fluids. Vaginal secretions are primarily from the uterus, cervix, and transudation of the vaginal epithelium in addition to miniscule vaginal lubrication from the Bartholin's glands upon sexual arousal. It takes little vaginal secretion to make the vagina moist. The secretions may be minor in excess during sexual arousal, the middle of the menstrual cycle, a little prior to menstruation, or during pregnancy.[16]

The Bartholin's glands, located near the vaginal opening and cervix, were originally thought to be the primary source for vaginal lubrication, but they provide only a few drops of mucus for vaginal lubrication;[30] the significant majority of vaginal lubrication is generally believed to be provided by plasma seepage from the vaginal walls, which is called vaginal transudation. Vaginal transudation, which initially forms as sweat-like droplets, is caused by vascular engorgement of the vagina (vasocongestion); this results in the pressure inside the capillaries increasing the transudation of plasma through the vaginal epithelium.[30][31][32]

Before and during ovulation, the cervix's mucus glands secrete different variations of mucus, which provides an alkaline, fertile environment in the vaginal canal that is favorable to the survival of sperm.[33] As women age, vaginal lubrication decreases, which does not necessarily mean that a physical or psychological problem exists.[34] After menopause, the body produces less estrogen, which, unless compensated for with estrogen replacement therapy, causes the vaginal walls to thin out significantly.[16][24][35]

Sexual activity

In general, the concentration of the nerve endings that lie close to the entrance of a woman's vagina (the lower third) can provide pleasurable vaginal sensations during sexual activity when stimulated, and many women additionally derive pleasure from a feeling of closeness and fullness during penetration of the vagina.[36][37] The vagina as a whole, however, lacks nerve endings, which commonly hinders a woman's ability to receive sufficient sexual stimulation, including orgasm, solely from vaginal sexual activity.[36][37][38] Although some scientific examinations of vaginal wall innervation indicate no single area with a greater density of nerve endings, or that only some women have a greater density of nerve endings in the anterior vaginal wall,[39][40] heightened sensitivity in the anterior vaginal wall is common among women.[39][41] These cases indicate that the outer one-third of the vagina, especially near the opening, contains the majority of the vaginal nerve endings, making it more sensitive to touch than the inner (or upper) two-thirds of the vaginal barrel.[36][38][42] This factor is considered to make the process of child birth significantly less painful, because an increased number of nerve endings means that there is an increased possibility for pain as well as pleasure.[36][43][44]

Besides penile penetration, there are a variety of ways that pleasure can be received from vaginal stimulation, including by masturbation, fingering, oral sex (cunnilingus), or by specific sex positions (such as the missionary position or the spoons sex position).[45] Some women use sex toys, such as a vibrator or dildo, for vaginal pleasure.[46] Foreplay is often used to incite sexual arousal, and may include one or more of the aforementioned sexual activities. The clitoris additionally plays a part in vaginal stimulation, as it is a sex organ of multiplanar structure containing an abundance of nerve endings, with a broad attachment to the pubic arch and extensive supporting tissue to the mons pubis and labia; it is centrally attached to the urethra, and research indicates that it forms a tissue cluster with the vagina. This tissue is perhaps more extensive in some women than in others, which may contribute to orgasms experienced vaginally.[38][47][48]

During sexual arousal, and particularly the stimulation of the clitoris, the walls of the vagina lubricate. This begins after ten to thirty seconds of sexual arousal, and increases in amount the longer the woman is aroused.[49] It reduces friction or injury that can be caused by insertion of the penis into the vagina or other penetration of the vagina during sexual activity.[2] The vagina lengthens during the arousal, and can continue to lengthen in response to pressure; as the woman becomes fully aroused, the vagina expands in length and width, while the cervix retracts.[49][50] With the upper two-thirds of the vagina expanding and lengthening, the uterus rises into the greater pelvis, and the cervix is elevated above the vaginal floor, resulting in "tenting" of the mid-vaginal plane.[49] As the elastic walls of the vagina stretch or contract, with support from the pelvic muscles, to wrap around the inserted penis (or other object),[2][42] this stimulates the penis and helps to cause the male to experience orgasm and ejaculation, which in turn enables fertilization.[2]

An area in the vagina that may be an erogenous zone is the G-spot (also known as the Gräfenberg spot); it is typically defined as being located at the anterior wall of the vagina, a couple or few inches in from the entrance, and some women experience intense pleasure, and sometimes an orgasm, if this area is stimulated during sexual activity.[39][41] A G-spot orgasm may be responsible for female ejaculation, leading some doctors and researchers to believe that G-spot pleasure comes from the Skene's glands, a female homologue of the prostate, rather than any particular spot on the vaginal wall. Other researchers consider the connection between the Skene's glands and the G-spot area to be weak; they contend that the Skene's glands do not appear to have receptors for touch stimulation, and that there is no direct evidence for their involvement.[39][40][41] The G-spot's existence, and existence as a distinct structure, is still under dispute, as its reported location can vary from woman to woman, appears to be nonexistent in some women, and it is hypothesized to be an extension of the clitoris and therefore the reason for orgasms experienced vaginally.[39][43][48]

Childbirth

The vagina provides a channel to deliver a newborn from the uterus to its independent life outside the body of the mother. When childbirth (or labor) nears, several symptoms may occur, including Braxton Hicks contractions, vaginal discharge, and the rupture of membranes (water breaking).[51] When water breaking happens, there may be an uncommon wet sensation in the vagina, on the perineum, an irregular or steady small stream of fluid from the vagina, or a gush of fluid.[52][53]

When the body prepares for childbirth, the cervix softens, thins, moves forward to face anteriorly, and may begin to open. This allows the fetus to settle or "drop" into the pelvis.[51] When the fetus settles into the pelvis, this may result in pain in the sciatic nerves, increased vaginal discharge, and increased urinary frequency. While, for women who have given birth before, these symptoms are likelier to happen after labor has already begun, they may happen approximately ten to fourteen days before labor in women experiencing the effects of nearing labor for the first time.[51]

The fetus begins to lose the support of the cervix when uterine contractions begin. With cervical dilation reaching a diameter of more than 10 cm (4 in) to accommodate the head of the fetus, the head moves from the uterus to the vagina.[51] The elasticity of the vagina allows it to stretch to many times its normal diameter in order to deliver the child.[20]

Births are usually successful vaginal births, but there are sometimes complications and a woman may undergo a cesarean section instead of a vaginal delivery. The vaginal mucosa has an abnormal accumulation of fluid (edematous) and is thin, with few rugae, a little after birth. The mucosa thickens and rugae return in approximately three weeks once the ovaries regain usual function and estrogen flow is restored. The vaginal opening gapes and is relaxed, until it returns to its approximate pre-pregnant state by six to eight weeks in the period beginning immediately after the birth (the postpartum period); however, it will maintain a larger shape than it previously had.[54]

Vaginal ecosystem and acidity

The vagina is a nutrient rich environment that harbors a unique and complex microbiome. It is a dynamic ecosystem that undergoes long term changes, from neonate to puberty and from the reproductive period (menarche) to menopause. Moreover, under the influence of hormones, such as estrogen (estradiol), progesterone and follicle stimulating hormone (FSH), the vaginal ecosystem undergoes cyclic or periodic changes, i.e. during menses and pregnancy.[55] One significant variable parameter is the vaginal pH, which varies significantly during a woman's lifespan, from 7.0 in premenarchal girls, to 3.8-4.4 in women of reproductive age to 6.5-7.0 during menopause without hormone therapy and 4.5-5.0 with hormone replacement therapy.[56] Estrogen, glycogen and lactobacilli are important factors in this variation.[55][56]

Clinical significance

General

An ultrasound showing the urinary bladder (1), uterus (2), and vagina (3)

The vagina is self-cleansing and therefore usually needs no special treatment. To maintain vulvovaginal health, doctors generally discourage the practice of douching.[57] Since a healthy vagina is colonized by a mutually symbiotic flora of microorganisms that protect its host from disease-causing microbes, any attempt to upset this balance may cause many undesirable outcomes, including but not limited to abnormal discharge and yeast infection.[57]

The vagina and cervix are examined during gynecological examinations of the pelvis, often using a speculum, which holds the vagina open for visual inspection or taking samples (see pap smear).[58] This and other medical procedures involving the vagina, including digital internal examinations and administration of medicine,[58][59] are referred to as being "per vaginam", the Latin for "via the vagina",[60] often abbreviated to "p.v.".[59]

A disposable plastic bi-valved vaginal speculum used in gynecological examination

The healthy vagina of a woman of child-bearing age is acidic, with a pH normally ranging between 3.8 and 4.5., and this is due to the degradation of glycogen to the lactic acid by enzymes secreted by the Döderlein's bacillus, which is a normal commensal of the vagina.[55] The acidity retards the growth of many strains of pathogenic microbes.[55][61] An increased pH of the vagina (with a commonly used cut-off of pH 4.5 or higher) can be caused by bacterial overgrowth, as occurs in bacterial vaginosis and trichomoniasis, or rupture of membranes in pregnancy.[55][62]

Intravaginal administration is a route of administration where the substance is applied to the inside of the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration.[63][64]

Diseases

Diseases that can affect the vagina include sexually transmitted infections (STIs/STDs) such as HIV/AIDS, human papillomavirus (HPV), genital herpes, or trichomoniasis, or other infections such as candidal vulvovaginitis. Because of STIs, health authorities and other health outlets recommend safe sex practices when engaging in sexual activity.[3][4] Vaginitis is an inflammation of the vagina, and is attributed to several vaginal diseases, while vaginismus is an involuntary tightening of the vagina muscles caused by a conditioned reflex, or to disease conditions in the area, during vaginal penetration.[65]

There can be a vaginal obstruction, such as by imperforate hymen or, less commonly, a transverse vaginal septum. Where a lump is present in the vagina, it is most commonly a Bartholin's cyst.[66] Vaginal prolapse is characterized by a portion of the vaginal canal protruding (prolapsing) from the opening of the vagina. It may result in the case of weakened pelvic muscles, which is a common result of childbirth; in the case of this prolapse, the rectum, uterus, or bladder pushes on the vagina, and severe cases result in the vagina protruding out of the body. Kegel exercises have been used to strengthen the pelvic floor, and may help prevent or remedy vaginal prolapse.[67] Cervical cancer may be prevented by pap smear screening and HPV vaccines. Vaginal cancer is very rare, and is primarily a matter of old age; its symptoms include abnormal vaginal bleeding or vaginal discharge.[68][69]

Modification

The vagina, including the vaginal opening, may be altered as a result of genital modification during vaginoplasty or labiaplasty; for example, alteration to the inner labia (also known as the vaginal lips or labia minora). There is no evidence that such surgery improves psychological or relationship problems; however, the surgery has a risk of damaging blood vessels and nerves.[70]

Female genital mutilation (FGM), another aspect of female genital modification, may additionally be known as female circumcision or female genital cutting (FGC).[71][72] FGM has no known health benefits. The most severe form of FGM is infibulation, in which there is removal of all or part of the inner and outer labia (labia minora and labia majora) and the closure of the vagina; this is called Type III FGM, and it involves a small hole being left for the passage of urine and menstrual blood, with the vagina being opened up for sexual intercourse and childbirth.[72]

Society and culture

Biological perceptions, symbolism and vulgarity

There have been various perceptions of the vagina throughout history, which range from the view that it is the center of sexual desire, a symbol of sexual power, a metaphor for life via birth, inferior to the penis, visually unappealing, inherently "smelly," or otherwise vulgar.[73][74][75] These views can largely be attributed to sex differences, and how they are interpreted. Evolutionary psychologist David Buss stated that because a penis is significantly larger than a clitoris and it is "on display and ready to be noticed" while the vagina is not, and males urinate through the penis, boys are taught from childhood "to touch and hold their penises" while girls are often taught that they should not touch their own genitals, "as if their genitals were a biohazard zone." Buss attributed this to the reason why many women are not as familiar with their genitalia as men are familiar with their own, and that researchers assume these sex differences explain why boys learn to masturbate before girls, and masturbate more often than girls.[76]

The word vagina is commonly avoided,[77] and many men in addition to women do not know that the vagina is not used for urination.[78][79][80] This is exacerbated by the phrase "Boys have a penis, girls have a vagina.", which causes children to think that girls have one orifice in the pelvic area.[79] Author Hilda Hutcherson stated, "Because many of us [women] have been conditioned since childhood through verbal and nonverbal cues to think of our genitals as ugly, smelly and unclean, we aren't able to fully enjoy intimate encounters because of fear that our partner will be turned off by the sight, smell, and taste of our genitals." She added that women, unlike men, did not have locker room experiences in school where they compared each other's genitals, and so many women wonder if their genitals are normal.[74] Scholar Catherine Blackledge stated that having a vagina meant she would typically be treated less well than a "vagina-less person" and that she "could be expected to work all [her] life for less money than if [she] was minus female genitalia"; it meant she "could expect to be treated as a second-class citizen".[77]

Negative views of the vagina are simultaneously contrasted by views that it is a powerful symbol of female sexuality, spirituality, or life. Author Denise Linn stated, "[The vagina] is a powerful symbol of womanliness, openness, acceptance, and receptivity. It is the inner valley spirit."[81] Sigmund Freud placed significant value on the vagina,[82] postulating the concept of vaginal orgasm, that it is separate from clitoral orgasm, and that, upon reaching puberty, the proper response of mature women is a change-over to vaginal orgasms (meaning orgasms without any clitoral stimulation). This theory, however, made many women feel inadequate, as the majority of women cannot achieve orgasm via vaginal intercourse alone.[83][84][85] Regarding religion, the vagina represents a powerful symbol as the yoni in Hindu, and this may indicate the value that Hindu society has given female sexuality and the vagina's ability to birth life.[86]

In Ancient times, the vagina was often considered equivalent (homologous) to the penis; anatomists Galen (129 AD – 200 AD) and Vesalius (1514–1564), regarded the organs as structurally the same, except for the vagina being inverted. Anatomical studies over latter centuries, however, showed the clitoris to be the penile equivalent.[47][87] The release of vaginal fluids were considered by medical practitioners to cure or remedy a number of ailments; various methods were used over the centuries to release "female seed" (via vaginal lubrication or female ejaculation) as a treatment for suffocation ex semine retento (suffocation of the womb), female hysteria or green sickness. Methods included a midwife rubbing the walls of the vagina or insertion of the penis or penis-shaped objects into the vagina. Supposed symptoms of female hysteria included faintness, nervousness, insomnia, fluid retention, heaviness in abdomen, muscle spasm, shortness of breath, irritability, loss of appetite for food or sex, and "a tendency to cause trouble".[88] Women considered suffering from the condition would sometimes undergo "pelvic massage" — stimulation of the genitals by the doctor until the woman experienced "hysterical paroxysm" (i.e., orgasm). Paroxysm was regarded as a medical treatment, and not a sexual release.[88] The categorization of female hysteria has ceased to be recognized as a medical condition since the 1920s.

The vagina has additionally been termed many vulgar names,[89] two being cunt and pussy. Cunt is used as a derogatory epithet referring to people of either sex. This usage is relatively recent, dating from the late nineteenth century.[90] Reflecting different national usages, cunt is described as "an unpleasant or stupid person" in the Compact Oxford English Dictionary, whereas Merriam-Webster has a usage of the term as "usually disparaging and obscene: woman",[91] noting that it is used in the U.S. as "an offensive way to refer to a woman";[92] and the Macquarie Dictionary of Australian English states that it is "a despicable man". When used with a positive qualifier (good, funny, clever, etc.) in Britain, New Zealand and Australia, it can convey a positive sense of the object or person referred to.[93] Pussy, on the other hand, can indicate "cowardice or weakness", and "the human vulva or vagina" or by extension "sexual intercourse with a woman".[94]

In contemporary art and literature

The Vagina Monologues, a 1996 episodic play by Eve Ensler, has been noted for its success in making female sexuality a topic of public discourse. It is made up of a varying number of monologues read by a number of women. Initially, Ensler performed every monologue herself, with subsequent performances featuring three actresses; latter versions feature a different actress for every role. Each of the monologues deals with an aspect of the feminine experience, touching on matters such as sexual activity, love, rape, menstruation, female genital mutilation, masturbation, birth, orgasm, the various common names for the vagina, or simply as a physical aspect of the body. A recurring theme throughout the pieces is the vagina as a tool of female empowerment, and the ultimate embodiment of individuality.[89][95]

In Japan, artist Megumi Igarashi has drawn attention for her work featuring vaginas, which she considers "overly hidden" in Japan compared to male genitalia.[96]

Reasons for vaginal modification

Reasons for modification of the external female genitalia includes voluntary cosmetic operations and surgery for intersex conditions, which can involve surgery to the vagina, labia minora, or clitoris.[70] It also includes FGM.[97] There are two main categories of women seeking cosmetic genital surgery: those with congenital conditions such as an intersex condition, and those with no underlying condition who experience physical discomfort or wish to alter the appearance of their genitals because they believe they do not fall within a normal range.[70]

Significant controversy surrounds FGM,[71][72] with the World Health Organization (WHO) being one of many health organizations that have campaigned against the procedures on behalf of human rights, stating that it is "a violation of the human rights of girls and women" and "reflects deep-rooted inequality between the sexes".[72] FGM has existed at one point or another in almost all human civilizations,[97] most commonly to exert control over the sexual behavior, including masturbation, of girls and women.[72][97] It is carried out in several countries, especially in Africa, and to a lesser extent in other parts of the Middle East and Southeast Asia, on girls from a few days old to mid-adolescent, often to reduce sexual desire in an effort to preserve vaginal virginity.[71][72][97] It may also be that FGM was "practiced in ancient Egypt as a sign of distinction among the aristocracy"; there are reports that traces of infibulation are on Egyptian mummies.[97]

Custom and tradition are the most frequently cited reasons for FGM, with some cultures believing that not performing it has the possibility of disrupting the cohesiveness of their social and political systems, such as FGM also being a part of a girl's initiation into adulthood.[72][97] Often, a girl is not considered an adult in a FGM-practicing society unless she has undergone FGM.[72]

Other animals

The vagina (along with the penis) is a general feature of animals in which the female is internally fertilised (other than by traumatic insemination). The shape of the vagina varies among different animals.

In placental mammals and marsupials, the vagina leads from the uterus to the exterior of the female body. Female marsupials have two lateral vaginas, which lead to separate uteri, but both open externally through the same orifice.[98] The urethra and vagina of the female spotted hyena exits through the clitoris, allowing the females to urinate, copulate and give birth through the clitoris.[99] The canine female vagina contracts during copulation, forming a copulatory tie.[100]

In birds, monotremes, and some reptiles, a homologous part of the oviduct leads from the shell gland to the cloaca.[101][102] In some jawless fish, there is neither oviduct nor vagina and instead the egg travels directly through the body cavity (and is fertilised externally as in most fish and amphibians). In insects and other invertebrates, the vagina can be a part of the oviduct (see insect reproductive system).[103]

Females of some waterfowl species have developed vaginal structures called dead end sacs and clockwise coils to protect themselves from sexual coercion.[104]

In 2014, the scientific journal Current Biology reported that four species of Brazilian insects in the genus Neotrogla were found to have sex-reversed genitalia. The male insects of those species have vagina-like openings, while the females have penis-like organs.[105][106][107]

See also

References

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  • Media related to Vaginas at Wikimedia Commons
  • The dictionary definition of vagina at Wiktionary

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