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. 2015 Aug:101:38-41.
doi: 10.1016/j.rvsc.2015.05.016. Epub 2015 Jun 5.

Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2) viral loads in serum of postweaning multisystemic wasting syndrome (PMWS)-affected and healthy pigs in Brazil

Thais Fumaco Teixeira  1 , Samuel Paulo Cibulski  2 , Helton Fernandes dos Santos  3 , Adriéli Wendlant  3 , Francisco Esmaile de Sales Lima  4 , Candice Schmidt  3 , Ana Cláudia Franco  4 , Paulo Michel Roehe  2
Affiliations

Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2) viral loads in serum of postweaning multisystemic wasting syndrome (PMWS)-affected and healthy pigs in Brazil

Thais Fumaco Teixeira et al. Res Vet Sci. 2015 Aug.

Abstract

Associations between Torque teno sus viruses (TTSuVs) and the occurrence of postweaning multisystemic wasting syndrome (PMWS) have been reported with controversial results. Currently, no studies have been performed comparing simultaneously viral loads of TTSuVs and PCV2. To examine the role for TTSuVs in PMWS-affected animals, a SYBR Green-based quantitative PCR (qPCR) was designed to detect and quantify TTSuV1, TTSuV2 and PCV2 genomes in swine sera. TTSuV1 genome loads were significantly higher in healthy adults than in young and SPF animals (p<0.05) suggesting that the prevalence of TTSuV1 infection increases with age and bears no association with PMWS. Regarding TTSuV2, no significant variation was detected in viral loads within any of the groups. As expected, PCV2 genome loads were higher in PMWS-affected swine than in healthy or SPF animals (p<0.001). These findings provide clear evidence to indicate that neither TTSuV1 nor TTSuV2 viral loads have any correlation with the occurrence of PMWS.

Keywords: Anellovirus; Postweaning multisystemic wasting syndrome (PMWS); Quantitative PCR (qPCR); Torque teno sus virus (TTSuV).

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